CIS-DIAMINO-(2,2,6,6-TETRAMETHYLPIPERID-4-YL)-TETRACHLOROPLATINUM (IV) DIHYDRATE AND METHOD FOR ITS PREPARING Russian patent published in 2004 - IPC

Abstract RU 2240996 C1

FIELD: chemistry of metalloorganic compounds, medicine, oncology.

SUBSTANCE: invention relates to physiologically active compounds and concerns cis-diamino-(2,2,6,6-tetramethylpiperid-4-yl)-tetrachloroplatinum (IV) dihydrate and a method for its preparing. Method involves interaction of 4-amino-2,2,6,6-tetramethylpiperidine hydrochloride with potassium or sodium tetrachloroplatinate and the following isolation of the end product. Invention provides synthesis of new effective anti-metastatic preparations with reduced toxicity. Cis-diamino-(2,2,6,6-tetramethylpiperid-4-yl)-tetrachloroplatinum (IV) dihydrate can be used in medicinal practice as effective and nontoxic anti-metastatic medicinal agent instead highly toxic cisplatin.

EFFECT: valuable medicinal properties of compound, expanded assortment of agents with anti-tumor activity.

2 cl, 1 ex

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RU 2 240 996 C1

Authors

Fedorov B.S.

Sipjagin A.M.

Kozub G.I.

Konovalova N.P.

Volkova L.M.

Dates

2004-11-27—Published

2003-07-25—Filed