(DL)-1-HYDROXY-3,7,7,9,9-PENTAMETHYL-1,4,8-TRIAZASPIRO[4,5]DECANE-2-ONE AND METHOD FOR ITS PREPARING Russian patent published in 2004 - IPC

Abstract RU 2243227 C1

FIELD: organic chemistry, chemical technology, medicine.

SUBSTANCE: invention relates to (DL)-1-hydroxy-3,7,7,9,9-pentamethyl-1,4,8-triazaspiro[4,5]decane-2-one of the formula (1) .

Also, invention describes a method for preparing this compound by treatment of DL-alanine hydroxamic acid with ketone wherein aminoketone - 2,2,6,6-tetramethylpiperidine-4-one is used as ketone, and process is carried out in benzene medium in the mole ratio of reagents: α-aminohydroxamic acid : aminoketone = 1:1.1 followed by isolation of the end product. Invention provides preparing new compound that can be used as a nontoxic antimetastatic medicinal agent.

EFFECT: improved preparing method, valuable medicinal properties of compound.

3 cl, 1 ex

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RU 2 243 227 C1

Authors

Fedorov B.S.

Vystorop I.V.

Konovalova N.P.

Volkova L.M.

Dates

2004-12-27Published

2003-07-25Filed