DERIVATIVES OF PLATINUM TETRACHLORIDE AND METHOD FOR THEIR PREPARING Russian patent published in 2005 - IPC

Abstract RU 2245328 C1

FIELD: chemistry of metalloorganic compounds, medicine, oncology.

SUBSTANCE: invention relates to derivatives of platinum tetrachloride and to a method for their preparing also. Invention proposes compounds of the formula PtCl₄ x 2 Li wherein Li represents N-(2-nitroxyethyl)nicotinamide or N-(2-nitroxyethyl)isonicotinamide, or nicotine hydroxamic acid, or isonicotine hydroxamic acid. Also, invention proposes a method for preparing these compounds that involves interaction of pyridine carboxylic acid nitroxyethylamides or hydroxamic acids, or their hydrochlorides with potassium hexachloroplatinate followed by isolation of the end product. Invention provides synthesis of the unknown early chelate platinum compounds that are physiologically active substances and can be used in medicinal practice instead cisplatin as effective anti-metastatic medicinal agents with low toxicity.

EFFECT: improved preparing method, enhanced and valuable medicinal properties of compounds.

2 cl, 3 ex

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RU 2 245 328 C1

Authors

Fedorov B.S.

Fadeev M.A.

Kozub G.I.

Konovalova N.P.

Volkova L.M.

Dates

2005-01-27—Published

2003-07-25—Filed