FIELD: chemistry of metalloorganic compounds, medicine, oncology.
SUBSTANCE: invention relates to a method for synthesis of physiologically active compounds, namely: cis-cis-[4-nitraminopyridin-N]tetrachloroplatinum (IV) trimethylolaminomethane salt of the formula: PtCl4. 2Li wherein Li means compound of the formula: . Method involves interaction of 4-nitraminopyridine with potassium hexachloroplatinate followed by separating formed cis-bis-(4-nitramino-N)tetrachloroplatinum, its treatment with trimethylolaminomethane and isolation of the end substance. Synthesized compound can be used in medicinal practice as both a separate low-toxic anti-metastatic medicinal agent and in composition with the known preparations.
EFFECT: valuable medicinal properties of compound, improved method of synthesis.
2 cl, 1 ex
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Authors
Dates
2007-05-10—Published
2005-11-17—Filed