CIS-CIS-[4-NITRAMINOPYRIDIN-N]TETRACHLOROPLATINUM (IV) TRIMETHYLOLAMINOMETHANE SALT AND METHOD FOR ITS PREPARING Russian patent published in 2007 - IPC C07F15/00 A61K33/24 

Abstract RU 2298556 C1

FIELD: chemistry of metalloorganic compounds, medicine, oncology.

SUBSTANCE: invention relates to a method for synthesis of physiologically active compounds, namely: cis-cis-[4-nitraminopyridin-N]tetrachloroplatinum (IV) trimethylolaminomethane salt of the formula: PtCl4. 2Li wherein Li means compound of the formula: . Method involves interaction of 4-nitraminopyridine with potassium hexachloroplatinate followed by separating formed cis-bis-(4-nitramino-N)tetrachloroplatinum, its treatment with trimethylolaminomethane and isolation of the end substance. Synthesized compound can be used in medicinal practice as both a separate low-toxic anti-metastatic medicinal agent and in composition with the known preparations.

EFFECT: valuable medicinal properties of compound, improved method of synthesis.

2 cl, 1 ex

Similar patents RU2298556C1

Title Year Author Number
DERIVATIVES OF PLATINUM TETRACHLORIDE AND METHOD FOR THEIR PREPARING 2003
  • Fedorov B.S.
  • Fadeev M.A.
  • Kozub G.I.
  • Konovalova N.P.
  • Volkova L.M.
RU2245328C1
CIS-DIAMINO-(2,2,6,6-TETRAMETHYLPIPERID-4-YL)-TETRACHLOROPLATINUM (IV) DIHYDRATE AND METHOD FOR ITS PREPARING 2003
  • Fedorov B.S.
  • Sipjagin A.M.
  • Kozub G.I.
  • Konovalova N.P.
  • Volkova L.M.
RU2240996C1
METHOD FOR RACEMIC DIORGANOSILYL-BIS-(2-METHYLBENZO-[e]INDENYL)ZIRCONIUM COMPOUNDS DIASTEREOSELECTIVE SYNTHESIS, AND RACEMIC COMPOUND OF TRANSITION METAL 2003
  • Damrau Khans-Robert-Khell'Mut
  • Mjuller Patrik
  • Garsija Valeri
  • Sido Kristian
  • Tell'E Kristian
  • Lelon Zhan-Fransua
RU2337104C9
METHOD OF PRODUCING CHELATE CIS-S,S-COMPLEXES OF DICHLORODI-1,6-(3,5-DIMETHYL ISOXAZOLE-4-YL)-2,5-DITIAHEXANE PALLADIUM (II) AND PLATINUM (II) 2015
  • Akhmetova Vnira Rakhimovna
  • Akhmadiev Nail Salavatovich
  • Khisamutdinov Ravil Akhmetzyanovich
  • Ibragimov Askhat Gabdrakhmanovich
  • Dzhemilev Usein Memetovich
RU2596874C1
SUBSTITUTED FERROCENYL DIPHOSPHINES AS LIGANDS FOR HOMOGENEOUS CATALYSTS OF HYDRATION 2004
  • Shpindler Feliks
  • Lotts Mattias
  • Tommen Mark
RU2352577C2
CISPLATINUM COMPLEX AND METHOD FOR ITS PREPARING 2000
  • Vong Ehrnest S. J.
  • Dzhandomeniko Kristen M.
RU2245340C2
METHOD FOR PREPARING POTASSIUM OR AMMONIUM TRICHLOROAMMINE PLATINATE (II) FROM CIS-DICHLORODIAMMINE PLATINUM (II) 2005
  • Starkov Aleksandr Konstantinovich
  • Kazbanov Vladimir Il'Ich
  • Kozhukhovskaja Galina Anatol'Evna
RU2303571C2
MIXED CIS-DIAMINODICHLORODIHYDROXO PLATINUM (IV) COMPLEXES HAVING ANTITUMOR ACTIVITY 1987
  • Zheligovskaja N.N.
  • Fat'Kin A.Ju.
  • D'Jakova G.B.
  • Bokaeva S.S.
SU1563206A1
DIPHOSPHINE AND METAL COMPLEXES 2006
  • Kessel'Gruber Martin
  • Tommen Mark
  • Lotts Mattias
RU2408600C2
METHOD OF SYNTHESIS OF CIS-DICHLOROAMMINISOPROPYLAMINEPLATINUM (II) 1995
  • Kazbanov V.I.
  • Kozhukhovskaja G.A.
  • Starkov A.K.
RU2086559C1

RU 2 298 556 C1

Authors

Fedorov Boris Sergeevich

Kozub Galina Ivanovna

Fadeev Mikhail Arsen'Evich

Smirnov Vjacheslav Aleksandrovich

Mel'Nikov Mikhail Jakovlevich

Kondakov Sergej Ehmil'Evich

Dates

2007-05-10Published

2005-11-17Filed