WATER-SOLUBLE COMPLEX OF CIS-DIAMINODICHLOROPLATINUM (2+) WITH ISONIASIDE AND METHOD OF PREPARING SAID COMPLEX Russian patent published in 2010 - IPC C07D211/58 C07D213/86 C07F15/00 

FIELD: chemistry.

SUBSTANCE: invention relates to obtaining physiologically active compounds, particularly to a new water-soluble complex of cis-diaminodichloroplatinum (2+) with isonicotinic acid hydrazide of formula Pt(NH₃)₂Cl₂·2L, where L=INH is isoniaside, isonicotinic acid hydrazide. The method of preparing the complex involves reacting cis-diaminodichloroplatinum (2+) with isonicotinic acid hydrazide with subsequent extraction of the end product.

EFFECT: compound widens the range of water-soluble anti-tumour and anti-metastatic preparations; can be used in medical practice as an analogue of cisplatin on therapeutic effect, but in a more convenient form of administration due to its high solubility and low toxicity.

3 cl, 6 dwg, 1 ex