FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new N-(5-cyclopropyl-1-quinoline-5-yl-1H-pyrazole-4-carbonyl)guanidine monoethanolate and hemiethanolate, to crystalline forms of these ethanolates, methods for preparing ethanolates, methods for treatment using ethanolates and mesylate salt prepared by using ethanolates. Also, invention relates to pharmaceutical composition eliciting inhibitory activity with respect to sodium-hydrogen exchange of type 1 (NHE-1) based on these compounds. Invention provides preparing new compounds and pharmaceutical compositions based on thereof for aims of prophylaxis and reducing tissue damage arisen as result ischemia or hypoxia.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
15 cl, 8 tbl, 8 ex
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF N-(5-CYCLOPROPYL-1-QUINOLINE-5-YL-1H-PYRAZOLE-4-CARBONYL)-GUANIDINE MONOMESYLATE SALT |
2000 |
|
RU2190605C2 |
| METHOD FOR PRODUCING A POLYMORPHIC FORM OF 3-[5-AMINO-4-(3-CYANOBENZOYL)PYRAZOLE-1-YL]-N-CYCLOPROPYL-4-METHYLBENZAMIDE |
2017 |
- Suleiman, Osama
- Perez, Lucia Romero
- Harlacher, Cornelius Stephan
- Jones, Stewart
|
RU2792728C2 |
| METHOD FOR PRODUCING POLYMORPH FORM OF 3-[5-AMINO-4-(3-CYANOBENZOYL)PYRAZOLE-1-YL]-N-CYCLOPROPYL-4-METHYLBENZAMIDE |
2017 |
- Suleiman, Osama
- Perez, Lucia Romero
- Harlacher, Cornelius Stephan
- Jones, Stewart
|
RU2765719C2 |
| SUCCINATE 2-((4-(1-METHYL-4-(PYRIDIN-4-YL)-1H-PYRAZOL-3-YL)PHENOXY)METHYL)QUINOLINE SALT |
2007 |
- Vorkhost Patrik Robert
- Proulks Kehrolin
|
RU2430918C2 |
| CRYSTALLINE FORMS AND TWO SOLVATE FORMS OF LACTIC ACID SALTS 4-AMINO-5-FLUORINE-3-[5-(4-METHYLPIPERAZIN-1-YL)-1-H-BENZIMIDAZOL-2-YL]QUINOLINE-2(1H)ONE |
2009 |
- Zhiron Dan'Elle
- Khammershmidt Val'Ter
- P'Eshon Filipp
- Polazek Jokhanne
- Shrajner Andreas
- Shtovasser Frank
|
RU2497820C2 |
| CRYSTALLINE AND OTHER FORMS OF SALTS OF LACTIC ACID AND 4-AMINO-5-FLUORINE-3-[6-(4-METHYLPIPERAZINE-1-YL)-1H-BENZIMIDAZOLE-2-YL]-1H-QUINOLINE-2-ONE |
2006 |
- Okkhamafe Ogastus
- Chou Dzhojs
- Gallapalli Rampurna
- Kharvud Ehrik
- Rikman Dejvid
- Shuguan Chzhu
- Shan Sjao
|
RU2425041C2 |
| NEW CRYSTALLINE FORM OF 2-{3-[2-(1-{[3,5-BIS(DIFLUOROMETHYL)-1H-PYRAZOL-1-YL]ACETYL}PIPERIDIN-4-YL)-1,3-THIAZOL-4-YL]-4,5-DIHYDRO-1,2-OXAZOL-5-YL}-3-CHLOROPHENYLMETHANE SULPHONATE |
2014 |
- Olenik Britta
- Khillebrand Shtefan
- Vasner Perr
- Vajss Martin
- Vakhendorff-Nojmann Ulrike
|
RU2691948C2 |
| METHOD FOR PRODUCING 2-[(3R)-3-METHYLMORPHOLIN-4-YL]-4-(1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-5-YL)-1,7-NAFTHYRIDINE |
2019 |
- Platzek Johannes
- Rubenbauer Philipp
- Van Der Haas Hendricus Nicolaas Sebastiaan
- Hoogeveen Sonja Elisabeth
- Van Oers Matthijs Cornelis Maria
- Gieling Reinerus Gerardus
- Dekker Jeroen Alexander
|
RU2802512C2 |
| AZA-ARYL-1-H-PYRAZOL-1-YL-SULPHONAMIDES |
2013 |
- Chen Ksi
- Fan Yunfa
- Fan Pingchen
- Krasinski Antoni
- Li Lianfa
- Lui Rebekka M
- Mkmakhon Dzheffrej P.
- Povers Dzhej P.
- Zeng Yuibin
- Zhang Penglie
|
RU2627268C2 |
| METHOD OF PRODUCING N-{5-[3-(THIOPHENE-2-CARBONYL)-PYRAZOLE[1,5-a]PYRIMIDIN-7-YL]-2-FLUORO-PHENYL}-N-METHYL-ACETAMIDE IN POLYMORPHIC MODIFICATION B |
2007 |
- Anglada Luis
- Gul'Etta Antonio
- Palomer Al'Bert
|
RU2404984C1 |
