FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a method of synthesis of N-(5-cyclopropyl-1-quinoline-5-yl-1H-pyrazole-4-carbonyl)-guanidine monomesylate salt involving an interaction of N-(5-cyclopropyl-1-quinoline-5-yl-1H-pyrazole-4-carbonyl)-guanidine with methanesulfonic acid in a polar aprotonic solvent at temperature from 40 to 80 C. EFFECT: improved method of synthesis. 10 cl, 1 sch, 6 ex
| Title |
Year |
Author |
Number |
| N-(5-CYCLOPROPYL-1-QUINOLINE-5-YL-1H-PYRAZOLE-4-CARBONYL)GUANIDINE ETHANOLATES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THESE COMPOUNDS AND METHOD FOR PREPARING N-(5-CYCLOPROPYL-1-QUINOLINE-5-YL-1H-PYRAZOLE-4-CARBONYL)GUANIDINE MESYLATE SALT |
2001 |
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|
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2000 |
|
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1999 |
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|
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RU2297999C2 |
