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2 425 041

(13)

(51)

IPC

C07D401/14(2006-01-01)

A61K31/496(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2007147427/04, 2006-05-23

(24)

Start date

2006-05-23

(22)

Actual filing date

2006-05-23

(45)

Published

2011-07-27

(72)

Inventor

Okkhamafe OgastusChou DzhojsGallapalli RampurnaKharvud EhrikRikman DejvidShuguan ChzhuShan Sjao

(73)

Holder

Novartis Ag

CRYSTALLINE AND OTHER FORMS OF SALTS OF LACTIC ACID AND 4-AMINO-5-FLUORINE-3-[6-(4-METHYLPIPERAZINE-1-YL)-1H-BENZIMIDAZOLE-2-YL]-1H-QUINOLINE-2-ONE Russian patent published in 2011 - IPC C07D401/14 A61K31/496 A61P35/00

Abstract RU 2425041 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a crystalline hydrate of a salt of lactic acid and 4-amino-5-fluorine-3-[6-(4-methylpiperazine-4-yl)-1H-benzimidazole-2-yl]-1H-quinoline-2-one (compound of formula I):

, where said crystalline hydrate shows an X-ray powder pattern containing characteristic peaks located at the angles 2θ equal to approximately 17.6° approximately 19.3° and approximately 26.0°. Besides, the invention refers to compositions, drugs and dosage forms of such hydrates, and also to methods of treating patients suffering from cancer based on the administration of the presented crystalline hydrates.

EFFECT: preparation of the compounds for the patients suffering from cancer on the basis of of the salt of the crystalline hydrates.

21 cl, 4 tbl, 17 ex, 13 dwg

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RU 2 425 041 C2

Authors

Okkhamafe Ogastus

Chou Dzhojs

Gallapalli Rampurna

Kharvud Ehrik

Rikman Dejvid

Shuguan Chzhu

Shan Sjao

Dates

2011-07-27—Published

2006-05-23—Filed