SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USING AS INHIBITORS OF ALIPHATIC ACIDS OXIDATION Russian patent published in 2007 - IPC C07D417/14 C07D413/14 A61K31/496 

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to compound of the formula (I): wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ represent hydrogen atom or (C₁-C₆)-alkyl; T represents oxygen atom; V represents N<; X¹ represents phenyl substituted with 1-2 substitutes chosen from group comprising (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group, halogen atom, cyano-group or trifluoromethyl; X² represents a bicyclic heteroaryl comprising 7 carbon atoms and 1-2 heteroatoms chosen from oxygen (O), nitrogen (N) and sulfur (S) atoms optionally substituted with (C₁-C₆)-alkyl, (C₃-C₆)-cycloalkyl, phenyl or phenyl substituted with halogen atom; Y represents monocyclic heteroarylenyl comprising 3-5 carbon atoms and 1-3 heteroatoms chosen from N and O; Z¹ and Z² represent independently (C₁-C₄)-alkylene. Compounds of the formula (I) are used in preparing a pharmaceutical composition used in treatment of morbid state in mammal that can be relieved using inhibitor of oxidation of aliphatic acids. Also, invention relates to a pharmaceutical composition inhibiting oxidation of aliphatic acids and comprising at least one pharmaceutically acceptable excipient and the therapeutically effective dose of compound of the formula (I). Invention provides using substituted piperazine compounds as inhibitors of oxidation of aliphatic acids.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.

19 cl, 22 ex