METHOD FOR PREPARING CYCLO-(ARG-GLY-ASP-D-PHE-N-MEVAL) Russian patent published in 2005 - IPC

Abstract RU 2243974 C2

FIELD: organic chemistry, peptides, chemical technology.

SUBSTANCE: invention relates to a method for preparing cyclic pentapeptide: cyclo-(Arg-Gly-Asp-D-Phe-N-MeVal) by cyclization reaction of linear pentapeptide taken among the group consisting of: H-Arg(Pbf)-Gly-Asp(OBzl)-D-Phe-N-MeVal-OH, H-Gly-Asp(OBzl)-D-Phe-N-MeVal-Arg(Pbf)-OH, H-Asp(OBzl)-D-Phe-N-MeVal-Arg(Pbf)-Gly-OH, H-D-Phe-N-MeVal-Arg(Pbf)-Gly-Asp(OBzl)-OH or H-N-MeVal-Arg(Pbf)-Gly-Asp(OBzl)-D-Phe-OH followed by removal of protecting group and if necessary the further transformation of the end product to physiologically acceptable salts. Also, invention relates to linear pentapeptides taken among the group consisting of: H-Arg(Pbf)-Gly-Asp(OBzl)-D-Phe-N-MeVal-OH, H-Gly-Asp(OBzl)-N-MeVal-Arg(Pbf)-OH, H-Asp(OBzl)-D-Phe-N-MeVal-Arg(Pbf)-Gly-OH, H-D-Phe-N-MeVal-Arg(Pbf)-Gly-Asp(OBzl)-OH or H-N-MeVal-Arg(Pbf)-Gly-Asp(OBzl)-D-Phe-OH used as intermediate compounds in synthesis of cyclo-(Arg-Gly-Asp-D-Phe-N-MeVal).

EFFECT: improved method for synthesis.

6 cl, 1 tbl, 5 ex

Similar patents RU2243974C2

Title	Year	Author	Number
RGD-CONTAINING PEPTIDES	2001	Samukov V.V. Pozdnjakov P.I. Som Prantika Zamora Pol	RU2214416C2
CYCLOPEPTIDES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD OF ITS PREPARING	1996	Al'Fred Jonchik Simon Goodman Beate Difenbakh Arne Zutter Gjunter Khel'Tsemann Khorst Kessler Mikhel' Dekhantsrajter	RU2157379C2
CYCLIC INHIBITORS OF ADHESION	1997	Jonchik Al'Fred Goodman Simon Difenbakh Beate Kessler Khorst Koppitts Markus	RU2184121C2
DERIVATIVES OF HEMIN AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD FOR PREPARING, APPLICATION AND PHARMACEUTICAL COMPOSITION	2002	Evstigneeva R.P. Zheltukhina G.A. Zarubina T.V. Nebol'Sin V.E. Nosik D.N. Nosik N.N.	RU2238950C2
PEPTIDE VECTORS	2004	Dong Chzhen Ksin Shen Jilana Komstok Dzhinn Mehri Kim San Kh.	RU2361876C2
CYCLOPEPTIDES AND METHOD OF PREPARATION THEREOF	1995	Jonztsik Al'Fred Khel'Tsemann Gjunter Gudmen Sajmon Kessler Khorst Khaubner Roland Vermut Jokhen	RU2151776C1
BIOTIN DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF THEIR PREPARING	1996	Al'Fred Jonchik Simon Goodman Beate Difenbakh Khorst Kessler Dirk Finzinger	RU2171807C2
GLYCINE DERIVATIVES OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS SHOWING CAPABILITY TO INHIBIT FIBRINOGEN BINDING IN FIBRINOGEN PLATELET RECEPTOR	1990	Leo Alig[Ch] Albrekht Edenkhofer[Ch] Marsel Mjuller[Ch] Arnold Chechiak[De] Tomas Ueller[Ch]	RU2024549C1
TARGETING AMINOACID LIPIDS	2013	Placher Mikhael Vilkhelm Berendt Rajmond Gren Viola Khertner Simone Rashel Passafaro Marko Silvio Bauer Finn	RU2654210C2
COMPOSITIONS, CONTAINING CYCLIC PEPTIDES AND METHODS OF APPLYING THEREOF	2009	Zokhajla Antsali Al'Fred Jonchik	RU2555357C2

RU 2 243 974 C2

Authors

Jonchik Al'Fred

Arnol'D Markus

Dates

2005-01-10—Published

2000-03-01—Filed