TARGETING AMINOACID LIPIDS Russian patent published in 2018 - IPC C07D475/04 C07K5/02 C07K7/08 C07K7/64 A61K47/54 A61K9/127 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a carrier system comprising a compound of formula I and comprising ether-lipids conjugated to one or more bioactive ligands, which are exposed on the surface of the carrier system for use in targeted delivery and/or antigen display systems. Optionally one or more further bioactive agents may be encapsulated or embedded within, or attached to or adsorbed onto the carrier system. Also disclosed are compounds of formula I, where Y is O, N, S or a covalent bond, S₁, S₂, S₃ represent independently of each other a covalent bond or a spacer group, X₁, X₂, X₃ represent independently of each other H or a targeting ligand or an antigenic ligand, or a therapeutic ligand, or diagnostic ligand, or a combination thereof, L is a group of formula (a), wherein the dashed line represents the linkage to N, R₁ is H, R_1' is H, R₂ is H, R_2' is H or a group of formula -OR_d or -CH₂- OR_d, R₃ is H or a group of formula -(CH₂)₂-OR_e or -(CH₂)₃-OR_e, R_a, R_d, R_e represent independently of each other, straight or branched C (10-22)alkyl, C(10-22)alkenyl or C(10-22)alkynyl, m is 1, 2 or 3, provided that at least one of R₁, R₁', R₂, R₂', R₃ is not H, and at least one of X1, X₂, X₃ represents said ligand group.

EFFECT: for use in targeted delivery and/or antigen display systems.

15 cl, 22 ex, 2 dwg, 1 tbl