CYCLOPEPTIDES AND METHOD OF PREPARATION THEREOF Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: described are new cyclopeptides of formula I: cyclo-(Arg-A-Asp-R¹-R²) wherein A is Gly, R¹ is residue of 2-carboxy-8-amino-4-thiapiperolidin-9-one, O-aminomethyl -O¹-carboxybiphenyl, 2-aminomethyl-5- carboxymethylthiophene or residue of 2-(3-amino-1-pyrrolid-2-onyl)-4-methylpentanic acid (S)Gly(ANC-2)-Leu or (R)Gly(ANC-2)-Leu, residues being correspondingly connected through peptide bonds; R² is not defined, and also physicologically acceptable salts thereof. These compounds act as integrine inhibitors and are useful for prophylaxis and treatment of diseases of blood circulation, bones and antitumor therapy, and also as antiviral active agents. EFFECT: improved properties of the title compounds. 6 cl, 6 ex, 1 tbl