CYCLIC INHIBITORS OF ADHESION Russian patent published in 2002 - IPC

FIELD: peptides, pharmacy. SUBSTANCE: invention relates to cyclopeptides of the formula (I): Cyclo-(Arg-Gly-Asp-X-Y) where X means Phe, homo-Phe, Phg, Phe (4-F) or Phe (4-Cl); Y means hPro, Ahds, Aos, Nhdg, Acha, Aib, Acpa or Tle being in the case of residues of optically active amino acids and derivatives of amino acids D- and L-forms also and derivatives, especially β-ester of aspartic acid or N-guanidineacyl-derivatives of arginine, prodrugs and their physiologically acceptable salts. Compounds show high activity as inhibitors of integrin and also an anti-inflammatory effect. Invention describes also a method of synthesis of cyclopeptides and a pharmaceutical composition showing ability to inhibit integrin. EFFECT: valuable properties of cyclopeptides. 6 cl, 1 tbl