FIELD: organic chemistry, steroids, pharmacy.
SUBSTANCE: invention relates to a new type of selective estrogens comprising steroid structure of the general formula (I) 
with nonaromatic ring A and free of bound hydroxyl group at carbon atom 3 wherein R1 means hydrogen atom (H), (C1-C3)-alkyl or (C2-C3)-acyl; R2 means hydrogen atom (H), α-(C1-C4)-alkyl, α-(C2-C4)-alkenyl or α-(C2-C4)-alkynyl; R3 means hydrogen atom (H) or (C1-C4)-alkyl at position 16 of steroid structure; R4 means ethynyl; R5 means hydrogen atom (H), (C1-C3)-alkyl or (C2-C3)-acyl; R6 means (C1-C5)-alkyl, (C2-C5)-alkenyl, (C2-C5)-alkynyl being each of that is substituted optionally with chlorine or fluorine atom; dotted line means the optional double bond. Compounds of the formula (I) elicit the selective affinity to ERα-receptors.
EFFECT: valuable properties of compounds and composition.
4 cl, 3 sch, 1 tbl, 8 ex
| Title |
Year |
Author |
Number |
| STEROID COMPOUND, METHODS OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION |
1998 |
|
RU2182153C2 |
| STEROID COMPOUNDS, METHOD FOR SELECTIVE MODIFICATION, PHARMACEUTICAL COMPOSITION |
2001 |
|
RU2255090C2 |
| METHOD OF PREPARING 7β--SUBSTITUTED 4-AZA -5α- ANDROSTAN- 3-ONES AND METHOD OF PREPARING SUBSTITUTED 7β- ALKYL ANDROST-5-EN-3-ONES |
1993 |
- Raman K.Bakshi
- Gari Kh.Rasmusson
|
RU2114117C1 |
| 15β-SUBSTITUTED STEROIDS WITH SELECTIVE OESTROGENIC ACTIVITY |
2005 |
- Lozen Khubert Jan Jozef
- Ehderven Antonius Gerardus Khendrikus
- Dejks Frederikus Antonius
|
RU2386637C2 |
| 7-OXABICYCLOHEPTYL-SUBSTITUTED HETEROCYCLIC AMIDES OR STEREOISOMERS THEREOF AS THROMBOXANE RECEPTOR ANTAGONISTS |
1991 |
- Filip M.Sher[Us]
- Filip D.Stejn[Us]
- Dehvid Flojd[Us]
- Stiven E.Kholl[Us]
|
RU2015980C1 |
| METHOD FOR SYNTHESIS OF PHTHALASCIDINE AND INTERMEDIATE SUBSTANCES AND INTERMEDIATE COMPOUNDS |
2001 |
|
RU2267492C2 |
| HETEROCYCLIC COMPOUND |
1992 |
- Bruno Tamburini[It]
- Al'Chide Pervoni[It]
- Tino Rossi[It]
- Daniehle Donati[It]
- Daniehle Andreotti[It]
- Dzhovanni Gaviragi[It]
- Roberto Karlesso[It]
- Klaudio Bismara[It]
|
RU2054006C1 |
| PREPARATION FOR INHIBITING GLUCOSO-6-PHOSPHATASE SYSTEM FROM MAMMALIAN LIVER |
1993 |
- Khorst Khemmerle
- Peter Shindler
- Roland Utts
- Robert Rippel'
- Andreas Kherling
|
RU2131248C1 |
| 7-SUBSTITUTED FLUORO-2-β ACETYL-2-a, 4-a, 5, 12-TETRAOXY-1,2,3,4-TETRAHYDRO-6,11-NAPHTHACENEDIONES AS INTERMEDIATES FOR PREPARING ANTHRACYCLINE DERIVATIVES HAVING ANTITUMOR AND ANTIVIRAL ACTIVITY, ANTHRACYCLINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, NAPHTHACENEDIONES AS INTERMEDIATES FOR PREPARING 7-SUBSTITUTED FLUORO-2-b-ACETYL-2-a, 4-a, 5, 12-TETRAOXY-1, 2, 3, 4-TETRAHYDRO-6, 11-NAPHTACENEDIONE DERIVATIVES |
1990 |
- Alessandro Dzholitti[It]
- Antonio Gvidi[It]
- Franko Paskvi[It]
- Vittorio Pestellini[It]
- Federiko Arkamone[It]
|
RU2015958C1 |
| N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF NEUROGENIC INFLAMMATION |
1995 |
- Knud Ehrik Andersen
- Uffe Bang Ol'Sen
- Khans Petersen
- Frederik Kristian Grenval'D
- Ursula Sonneval'D
- Tine Krog Jergensen
- Khenrik Sune Andersen
|
RU2167152C2 |
