STEROID COMPOUND, METHODS OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention relates to steroid compound of the general formula (I) where means =O, -OH, OR or OOCR where R means alkyl group with from 1 to 6 carbon atoms; R₆ means H or where m = 1 or 2; R₇ means H, C_1-4- alkyl, C_2-4- alkenyl or C_2-4- alkynyl; R₁₁ means H, C_1-4- alkyl, C_2-4- alkenyl, C_2-4- alkynyl; E means (with exception of carbon atoms 16 and 17 of ring D) 4-7-membered hydrocarbon ring where indicated ring is at α- position with respect to ring D substituted with the group R_E, and comprises optionally one endocyclic double bond; R_E means H, C_1-5 alkyl, C_2-5- alkenyl, C_2-5- alkynyl, C_1-5- alkylidene, -(CH₂)_n-N₃ or -(CH₂)_n where n = 1 or 2 and where alkyl group can be substituted for OR, -OOCR where R is alkyl with 1-6 carbon atoms; R₁₇ means OH, -OR or OOCR where R means alkyl with 1-6 carbon atoms where indicated steroid compound can involve but optionally a single double bond, Δ5(10), Δ4(5) either ring A can be aromatic. The invention relates to also a pharmaceutical composition comprising the indicated steroid compound. Steroid compounds of the invention shows very high effectiveness for prophylaxis or treatment of disorders associated with per- or post menopause and, more preferably, for prophylaxis or treatment of osteoporosis. Except for, steroid compounds of the invention can be used as contraceptive agents. EFFECT: improved method of synthesis, valuable medicinal properties of steroid compound. 10 cl, 1 tbl, 8 ex