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2 522 806

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C1

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IPC

C12P1/00(2006-01-01)

C12P17/00(2006-01-01)

A61K31/22(2006-01-01)

C07C69/74(2006-01-01)

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Application

2012150683/10, 2012-11-27

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Start date

2012-11-27

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Actual filing date

2012-11-27

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Published

2014-07-20

(72)

Inventor

Skrjabin Konstantin GeorgievichDzhavakhija Vakhtang Vital'EvichGlagoleva Elena ViktorovnaPetukhov Dmitrij VladimirovichOvchinnikov Aleksandr Igorevich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Tsentr Rossijskoj Akademii Nauk

IMPROVED METHOD OF PURIFICATION OF PRAVASTATIN Russian patent published in 2014 - IPC C12P1/00 C12P17/00 A61K31/22 C07C69/74 

Abstract RU 2522806 C1

FIELD: biotechnology.

SUBSTANCE: purification of pravastatin is carried out from stereoisomer 6-epipravastatin. The culture liquid is centrifuged with a content of 6-epipravastatin 7% by weight of pravastatin for separation of mycelium. The native solution is prepared having pH 6.6. Purification of the native solution is carried out by filtration through a layer of basic alumina with pH 10, having activity corresponding to 8% of moisture. Alumina is taken in an amount of 25:1 relative to the amount of pravastatin in the native solution. Pravastatin is extracted by the organic solvent. Final purification of pravastatin is carried out through obtaining of intermediate ammonium salt using 25% aqueous ammonia solution and subsequent conversion to its sodium salt.

EFFECT: invention enables to carry out purification of pravastatin according to the pharmaceutical requirements to quality.

2 cl, 2 ex

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RU 2 522 806 C1

Authors

Skrjabin Konstantin Georgievich

Dzhavakhija Vakhtang Vital'Evich

Glagoleva Elena Viktorovna

Petukhov Dmitrij Vladimirovich

Ovchinnikov Aleksandr Igorevich

Dates

2014-07-20—Published

2012-11-27—Filed

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