FIELD: biochemistry, medicine, pharmacy.
SUBSTANCE: invention relates to preparing HMG-CoA-reductase inhibitor by displacement chromatography method. Inhibitor is taken among the group consisting of lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin and fluvastatin, their derivatives and analogues that are used as anti-hypercholesterolemic agents. The purity degree is the important factor in preparing the safety and effective medicinal agent, especially, if pharmaceutical preparation is used for a long time in treatment or prophylaxis of plasma blood high cholesterol level. Invention provides preparing HMG-CoA-reductase inhibitor with the high purity degree by HPLC data that enhance 99.7%, with high yield, reduced consumptions and suitable chemical balance.
EFFECT: improved preparing method.
27 cl, 14 ex
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