19-NORSTEROID DERIVATIVES, METHODS OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION AND INTERMEDIATE COMPOUNDS Russian patent published in 1998 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes compounds of formula (I) wherein $$$ and $$$ are such that $$$ and $$$ together form ketone, hydrozone, oxime or methylene group, or $$$ and $$$ are hydroxy group $$$ acyloxy; $$$ is hydrogen, $$$ alkyl, ethynyl, $$$ is hydrogen, linear $$$, cyalic $$$ alkyl, $$$ acyl; $$$ is hydrogen, halogen, $$$ alkyl, m is 0,1 or 2; X,Y and Z are such that X is methylene, phenylene or phenylenoxy bonded with steroid through carbon atom, saturated or unsaturated linear $$$ chain optionally terminated by oxygen atom; Z is linear $$$ alkyl, $$$ trifluoroalkyl, $$$ pentafluoroalkyl, nonafluorobutyl, substituted phenyl, compound addition salts. The present invention also describes preparation and use thereof as drug, compositions which comprise said compounds and novel intermediate products for preparation thereof $$$. EFFECT: improved properties of the pharmaceutical composition. 11 cl