FIELD: biotechnology, medicine.
SUBSTANCE: invention proposes the vaccine strain A/17/Panama/99/242 (H3N2) that represents reassortant prepared by breeding the epidemic strain A/Panama/200799 (H3N2) with cold-adopted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) as the attenuation donor that is harmless for adults. The strain A/17/Panama/99/242 (H3N2) multiplies actively in developing chicken embryos at optimal temperature 33-34oC and characterized by sensitivity to temperature and adaptation to cold. From the epidemic virus the reassortant inherited two genes encoding surface proteins (hemagglutinin and neuraminidase) and six genes encoding non-glycosylated proteins from the attenuation donor. The strain A/17/Panama/99/242 is areactogenic for adults in intranasal administration and satisfies to immunogenicity indices. The vaccine strain A/17/panama/99/242 (H3N2) satisfies to requirements by reactogenic indices to Pharmacopoeia article 42-3569-98 for vaccine strains of live anti-influenza vaccine used for intranasal applying in adults.
EFFECT: valuable properties of strain and vaccine.
1 dwg, 2 tbl, 1 ex
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