BICYCLIC AGONISTS OF VASOPRESSIN Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, hormones, pharmacy.

SUBSTANCE: invention relates to new biologically active compounds that act as agonists of peptide hormone vasopressin. Invention describes the compound of the general formula (1) or its pharmaceutically acceptable salt wherein V represents a covalent bond or NH; X is taken among CH₂, oxygen atom (O) and N-alkyl; Z represents sulfur atom (S) or -CH=CH-; R¹ and R² are taken independently among hydrogen (H), fluorine (F), chlorine (Cl), bromine (Br) atom and alkyl; R³ is taken among hydroxyl group (OH), O-alkyl and NR⁴R⁵ wherein each R⁴ and R⁵ represents independently hydrogen atom (H) or alkyl, or both represent -(CH₂)_q-; p = 0, 1, 2, 3 or 4; q = 4 or 5. Also, invention describes a pharmaceutical composition eliciting agonistic activity with respect to V₂-receptors, a method for treatment of enuresis, nicturia and diabetes insipidus, method for control of enuresis and a method for treatment of enuresis and a method for treatment of diseases associated with damage in blood coagulability. Invention provides preparing new compounds eliciting useful biological properties.

EFFECT: valuable medicinal properties of compounds.

17 cl, 31 ex