BENZOTHIA (DI) AZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS Russian patent published in 2025 - IPC C07D281/10 C07D285/36 A61K31/554 A61P1/16 A61P3/06 A61P3/08 A61P5/00 A61P9/00

Abstract RU 2838220 C1

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes individual derivatives of 1,5-benzothiazepine presented below, pharmaceutically acceptable salts thereof, a pharmaceutical composition based on them and use thereof.

M R¹ R² R³ R⁴ R⁵ CH₂ CH₂CH₂CH₂CH₃ CH₂CH₂CH₂CH₃ F SCH₃ F CH₂ CH₂CH₂CH₂CH₃ CH₂CH₃ F SCH₃ H CH₂ CH₂CH₂CH₂CH₃ CH₂CH₃ F SCH₃ F CH₂ CH₂CH₂CH₃ CH₂CH₃ H SCH₃ H CH₂ CH₂CH₂CH₃ CH₂CH₃ H SCH₃ F CH₂ CH(CH₃)₂ CH₂CH₃ H SCH₃ H CH₂ CH(CH₃)₂ CH₂CH₃ H SCH₃ F NH CH₂CH₂CH₂CH₃ CH₂CH₃ H N(CH₃)₂ H NH CH₂CH₂CH₂CH₃ CH₂CH₃ H N(CH₃)₂ F

See table above.

EFFECT: technical result is 1,5-benzothiazepine derivatives possessing activity of inhibition of apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transporter (LBAT).

8 cl, 8 tbl, 19 ex

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RU 2 838 220 C1

Authors

Gillberg Per-Goran

Starke Ingemar

Kulkarni Santosh S.

Dates

2025-04-14—Published

2020-12-04—Filed