BENZOTHIA(DI)AZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS Russian patent published in 2024 - IPC C07D281/10 C07D285/36 A61K31/554 A61P5/00

Abstract RU 2827704 C1

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, which have the activity of inhibiting apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transporter (LBAT). In formula (I) M is selected from -CH₂- and -NR⁷-; R¹ is C_1-4alkyl; R² is independently selected from the group consisting of hydrogen and halogen; n is equal to integer 1, 2 or 3; R³ is selected from the group consisting of C_1-4alkoxy, C_3-6cycloalkyloxy, C_1-4alkylthio and C_3-6cycloalkylthio; one of R⁴ and R⁵ is carboxyl, and the other of R⁴ and R⁵ is selected from the group consisting of hydrogen and fluorine; R⁶ is hydrogen and R⁷ is selected from the group consisting of hydrogen and C_1-4alkyl. Invention also relates to a pharmaceutical composition containing said compound and use thereof as a drug possessing the activity of inhibiting apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transporter (LBAT).

EFFECT: disclosed are benzothia(di)azepine compounds and use thereof as bile acid modulators.

14 cl, 4 dwg, 8 tbl, 62 ex

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RU 2 827 704 C1

Authors

Gillberg Per-G&Ouml

Ran

Starke Ingemar

Dates

2024-10-01—Published

2020-12-04—Filed