BENZOTHIA(DI)AZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS Russian patent published in 2024 - IPC C07D281/10 C07D285/36 A61K31/554 A61P5/00

Abstract RU 2827704 C1

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, which have the activity of inhibiting apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transporter (LBAT). In formula (I) M is selected from -CH₂- and -NR⁷-; R¹ is C_1-4alkyl; R² is independently selected from the group consisting of hydrogen and halogen; n is equal to integer 1, 2 or 3; R³ is selected from the group consisting of C_1-4alkoxy, C_3-6cycloalkyloxy, C_1-4alkylthio and C_3-6cycloalkylthio; one of R⁴ and R⁵ is carboxyl, and the other of R⁴ and R⁵ is selected from the group consisting of hydrogen and fluorine; R⁶ is hydrogen and R⁷ is selected from the group consisting of hydrogen and C_1-4alkyl. Invention also relates to a pharmaceutical composition containing said compound and use thereof as a drug possessing the activity of inhibiting apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transporter (LBAT).

EFFECT: disclosed are benzothia(di)azepine compounds and use thereof as bile acid modulators.

14 cl, 4 dwg, 8 tbl, 62 ex

Similar patents RU2827704C1

Title	Year	Author	Number
BENZOTHIA (DI) AZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS	2020	Gillberg Per-Goran Starke Ingemar Kulkarni Santosh S.	RU2838220C1
BENZOTHIA(DI)AZEPINES AND THEIR USE AS BILE ACID MODULATORS	2019	Jillberg, Per-Jeran Mattsson, Yan Starke, Ingemar Kulkarni, Santosh S.	RU2785867C2
BENZOTHIA(DI)AZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS	2021	Gillberg, Per-Goran Starke Ingemar Kulkarni Santosh S.	RU2841263C1
BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACIDS MODULATORS	2020	Gillberg, Per-Joran Mattson, Yan Starke, Ingemar Kulkarni, Santosh S.	RU2814570C2
BENZOTHIAZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS	2020	Gillberg Per-Goran Starke Ingemar Kulkarni Santosh S.	RU2838460C1
BENZOTHIADIAZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS	2020	Gillberg Per-Goran Starke Ingemar Kulkarni Santosh S.	RU2838136C1
BENZOTHIAZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS	2020	Gillberg, Per-Joran Mattson, Yan Starke, Ingemar Kulkarni, Santosh S.	RU2817535C2
N1/N2-LACTAM ACETYL-CoA-CARBOXYLASE INHIBITORS	2011	Bagley Scott William Dow Robert Lee Griffith David Andrew Smith Aaron Christopher	RU2540337C2
FGF21 DERIVATIVES AND USE THEREOF	2015	Vechorek Birgit Tagmose Tina Meller Sass-Erum Kristian Andersen Birgitta Olsen Jergen	RU2729011C2
TARTRATE 3-((1R,3R)-1-(2,6-DIFLUORINE-4-((1-(3- FLUOROPROPYL)AZETIDINE-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-b]INDOLE-2-YL)-2,2-DIFLUOROPROPANE-1-OL, ITS SOLID FORMS, METHOD OF ITS PREPARATION AND THEIR APPLICATION	2019	Chunk, Chol Keun Syuj, Tsze Iding, Khans Klagg, Kajl Delzil, Majkl Fettes, Alek Gosselin, Frensis Lim, Ngiap-Kie Makklori, Endryu Chzhan, Khajmin Chakravarti, Paroma Nagapudi, Kartik Robinson, Sara	RU2809220C2

RU 2 827 704 C1

Authors

Gillberg Per-G&Ouml

Ran

Starke Ingemar

Dates

2024-10-01—Published

2020-12-04—Filed