CONDENSED AZEPINES, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF, METHOD FOR TREATMENT BY USING INDICATED COMPOSITION Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new compounds of the general formula (1)

wherein A represents bicyclic or tricyclic azepine derivative; V¹ and V² both represent hydrogen atom (H) or one among V¹ and V² represents hydrogen atom (H), OMe, OBn, OPh, O-acyl, Br, Cl, F, N₃, NH₂, NHBn and another represents hydrogen atom (H); or V¹ and V² represent in common =O or -O(CH₂)_pO-; W¹ represents oxygen (O) or sulfur (S) atom; X¹ and X² both represent hydrogen atom (H) or in common represent =O or =S; Y represents OR⁵ or NR⁶R⁷; R¹ means hydrogen atom (H), lower alkyl, F, Cl and Br; R² means lower alkoxy-group or values given for R¹; R³ and R⁵ are taken independently among hydrogen atom (H) and lower alkyl; R⁴ means hydrogen atom (H); R⁶ and R⁷ are taken independently among hydrogen atom (H) and lower alkyl, or they in common mean -(CH₂)_n-; n = 3, 4, 5 or 6; p = 2 or 3. These compounds are agonists of vasopressin V₂ receptors and useful as antidiuretic and procoagulants, and also to pharmaceutical compositions comprising these vasopressin agonists. These compositions are useful especially in treatment of diabetes insipidus of the central origin and night enuresis.

EFFECT: valuable medicinal properties of compounds, improved method for treatment.

26 cl, 1 tbl, 119 ex