FIELD: medicine, experimental medicine, pharmacy.
SUBSTANCE: method involves culturing microorganism Escherichia coli on the nutrient medium agar-agar under aerobic conditions followed by addition of mixture containing Tc99m-pertechnatat, human albumin solution, physiological solution and culturing under anaerobic conditions. The prepared bacterial-isotope complex is subjected for dialysis for five stages. Method provides enhancing the lifetime content of isotope in the bacterial radiopharmaceutical preparation up to 77.7 MBk (62.9-92.5) in 1 ml wherein impurity of free technetium is 5%, not above. Method can be realized in small laboratory animals.
EFFECT: improved method for preparing.
1 tbl
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Authors
Dates
2005-07-10—Published
2003-05-26—Filed