NITRATE SALTS OF HYPOTENSIVE MEDICINAL AGENTS Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes nitrate salts of compounds taken among the following classes: class (A3): 1-isopropylamino-3-(1-naphthyloxy)-2-propanolol (propanolol); (S)-1-(tert.-butylamino)-3-(4-morpholino-1,2,5-thiadiazolyl-3-oxy)-2-propanol (timolol); 4-(2-hydroxy-3-isopropylaminopropoxy)phenylacetamide (atenolol); class (A2): 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazol[4,3-d]- pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine (sildenafil); 1-(2H)-phthalazinone hydrazone (hydralazine); 2-(2-propyloxyphenyl)-8-azapurine-6-one (zaprinast); 6-(1-piperidinyl)-2,4-pyirimidinediamine-3-oxide (minoxidil); class (A1c): (S)-N-valeryl-N-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]valine (valsartan); class (A4b): 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine carboxylic acid methyl-2-[methyl(phenylmethyl)-amino]ethyl ester (nicardipine); class (A4a): α-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]-methylamino]propyl]-3,4-dimethoxymethylethyl)benzene acetonitrile (verapamil); class (A7d): 3,5-diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide (amylorid); 2-(2,2-dicyclohexylethyl)-piperidine (perhexyline); clss (A1b): 2-n-butyl-4-chloro-5-hydroxymethyl-1-[2'-(tetrazol-5-yl)-biphenyl-4-yl]-imidazole (losartan) and 3,4-dihydroxyapomorphine nitrate (apomorphine). Invention describes also pharmaceutical compositions of nitrate salts by cl. 1 eliciting hypotensive activity. Invention provides preparing new salts of compounds eliciting the useful biological properties.

EFFECT: valuable medicinal properties of compounds.

8 cl, 10 tbl, 21 ex