METHOD FOR PREPARING COMPOSITION AS CARBONATED TABLET Russian patent published in 2005 - IPC

FIELD: medicine, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to a method for making compositions as carbonated tablets. Method involves granulation, drying, calibration, powdering and tableting. Method involves using anhydrous components and powder of each component is dried preliminary for 1 h, not less, at temperature below the decomposition point. Then powder components of active agent, basic and acid components providing the carbonated property are mixed being involving, if necessary, components of neutral substances, sweetening agents and special additives. Prepared mixture is granulated with 7-20% solution of a binding agent in isopropyl alcohol or ethanol and then the prepared granulate is dried at temperature not resulting to deterioration of granulate properties, to residual moisture 0.1-0.3%. Then method involves calibration of granules up to the size 1000-1200 mcm, powdering the prepared tablet mass and its tableting in moisture value of environment medium 5-25%. Invention provides reducing duration and labor intensity of the method due to exclusion the necessity carrying out the separate granulation of components and the development of technology providing the possibility for carrying out a single-step combined granulation of all components of the composition. Simplifying and acceleration of the method are attained in retention of high quality of ready tablets.

EFFECT: improved preparing method.

14 cl, 7 ex