FIELD: biotechnology, vaccines.
SUBSTANCE: method involves preparing industrial strain, smallpox scrape off and virus-containing liquid. Virus-containing liquid is inactivated by gamma-radiation Co60. Integral (total) dose of irradiation is 1.75 x 106 R at the parent specific activity of virus-containing liquid from 1 x 109 to 1.9 x 109 OOE/ml and 1.9 x 106 R at the parent specific activity of virus-containing liquid from 2 x109 to 5 x 10 OOE/ml. The content of total protein is brought about to the concentration 100 mcg/ml and drying stabilizing agents are added. Vaccine elicits high immunogenicity, suitable in applying and absence of toxicity.
EFFECT: improved preparing method, improved and valuable properties of vaccine.
3 cl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| A METHOD OF OBTAINING A SMALLPOX INACTIVATED EMBRYONIC DRY VACCINE IN TABLET FORM FOR ORAL ADMINISTRATION | 2020 |
|
RU2744707C1 |
| RABIES VACCINE PRODUCTION METHOD | 1986 |
|
SU1367487A1 |
| METHOD OF OBTAINING LIFE CULTURE VACCINE AGAINST INFLUENZA VIRUS | 2009 |
|
RU2420314C1 |
| INACTIVATED VACCINE AGAINST VENEZUELAN EQUINE ENCEPHALOMYELITIS AND A METHOD OF ITS PREPARING | 1991 |
|
RU2035191C1 |
| PENTAVALENT SUBUNIT VACCINE AGAINST RESPIRATORY INFECTIONS AND METHOD OF ITS PREPARATION | 2022 |
|
RU2804948C2 |
| METHOD OF OBTAINING MICROENCAPSULATED FORMS OF LIVE CULTURE VACCINE AGAINST SEASONAL AND PANDEMIC INFLUENZA FOR INTRANASAL USE | 2016 |
|
RU2617051C1 |
| METHOD OF PRODUCING ANTIGEN OR ANTIGENS FOR PRODUCTION OF INFLUENZA VACCINE AND A VACCINE BASED ON IT | 2019 |
|
RU2710239C1 |
| METHOD OF PRODUCTION OF LIVE CULTURE INFLUENZA VIRUS VACCINES | 2003 |
|
RU2330885C2 |
| METHOD OF STERILIZING FILTRATION OF VIRUS-CONTAINING MATERIAL FOR PRODUCING CULTURAL ANTI-RABIC VACCINE | 1989 |
|
RU1755580C |
| INACTIVATED FETAL DRY TABLETED SMALLPOX VACCINE FOR ORAL ADMINISTRATION OF “THAOVIN” AND A METHOD FOR ITS PREPARATION | 2016 |
|
RU2651040C2 |
