FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to the improved method for preparing a substance of the formula (IA) that inhibits the protein carrying out the transfer of cholesterol ester. Method involves using the new available intermediate compound of the formula (VIIIA) . Method involves interaction of compound of the formula (VIIIA) with 3,5-bis-(trifluoromethyl)benzyl halide in the presence of a base.
EFFECT: improved preparing method.
10 cl, 9 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PRODUCING 2-[(3R)-3-METHYLMORPHOLIN-4-YL]-4-(1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-5-YL)-1,7-NAFTHYRIDINE | 2019 |
|
RU2802512C2 |
METHODS FOR PREPARING SUBSTITUTED ARYL-CONDENSED AZAPOLYCYCLIC COMPOUNDS, INTERMEDIATE SUBSTANCES AND METHODS FOR THEIR PREPARING | 2002 |
|
RU2282619C9 |
SUBSTITUTED PYRIDINE COMPOUND | 2011 |
|
RU2572606C2 |
POLYCYCLIC ANTAGONISTS OF TLR7/8 AND THEIR USE IN TREATMENT OF IMMUNE DISORDERS | 2016 |
|
RU2783748C2 |
PYRIDINESULFONEAMIDE AND ITS SALTS, HYDRATES AND COMPLEXES WITH -ALCOHOLS USEFUL IN AGRICULTURE, HERBICIDE COMPOSITIONS, METHOD OF STRUGGLE AGAINST WEEDS, METHOD OF STRUGGLE AGAINST FOXTAIL (ALOPECURUS), AN INTERMEDIATE COMPOUND FOR ITS SYNTHESIS | 1993 |
|
RU2117666C1 |
METHOD FOR OBTAINING AZETIDINONE COMPOUNDS AND DERIVATIVES OF AZETIDINONE COMPOUNDS | 2015 |
|
RU2650687C1 |
PYRAZOLE COMPOUNDS SUBSTITUTED BY HETEROARYL AND THEIR APPLICATION IN PHARMACEUTICS | 2019 |
|
RU2805312C2 |
3-AMINOPYPERIDINE DERIVATIVES AND METHODS FOR PRODUCTION THEREOF | 2003 |
|
RU2309147C9 |
CCR-2 ANTAGONIST SALT | 2004 |
|
RU2317295C1 |
ALTERNATIVE METHODS FOR SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATE COMPOUNDS THEREOF | 2005 |
|
RU2411230C2 |
Authors
Dates
2005-08-27—Published
2002-04-08—Filed