DERIVATIVES OF AZAINDOLE Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives if azaindole of the formula (I)

or its pharmaceutically acceptable salts wherein the formula is taken among the group consisting of , , and and wherein each among R₁, R₂, R₃ and R₄ is taken independently among the group consisting of hydrogen atom (H), (C₁-C₆)-alkyl, (C₂-C₆)-alkenyl, halogen atom, cyano-group (CN), phenyl, nitro-group, -OC(O)R₁₅, -C(O)R₁₅, -C(O)OR₁₆, -OR₁₉, -SR₂₀ and NR₂₁R₂₂ wherein R₁₅ is taken independently among the group including hydrogen atom (H),(C₁-C₆)-alkyl and (C₂-C₆)-alkenyl; each among R₁₆, R₁₉ and R₀ is taken independently among the group including hydrogen atom (H), (C₁-C₆)-alkyl or (C₁-C₆)-alkyl substituted with from 1 to 3 halogen atoms; each among R₂₁ and R₂₂ is taken among the group including hydrogen atom(H), hydroxy-group (OH), (C₁-C₆)-alkyl; R₅ represents the group (O)_m wherein m = 0 or 1; n = 1 or 2; R₆ is taken among the group including hydrogen atom (H), (C₁-C₆)-alkyl, -C(O)R₂₄ and -C(O)OR₅ under condition that carbon atoms comprising carbon-carbon double bond of indicated (C₃-C₆)-alkenyl are not the addition point to nitrogen atom to which R₆ is joined; R₂₄ is taken among the group consisting of hydrogen atom (H), and (C₁-C₆)-alkyl; R₂₅ represents (C₁-C₆)-alkyl; each among R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃ and R₁₄ is taken independently among the group including hydrogen atom (H) and (C₁-C₆)-alkyl; Ar is taken among the group including:

, and . Compounds of the formula (I) inhibit HIV-1 that allows proposing their applying in medicine.

EFFECT: valuable medicinal and antiviral properties of compounds.

22 cl, 13 sch, 2 tbl