MULTITARGET INHIBITORS OF TUMOUR GROWTH BASED ON LINEAR HETEROARENE ANTHRACENEDIONES Russian patent published in 2014 - IPC C07D307/77 C07D333/50 C07D231/54 C07D209/56 A61K31/381 A61K31/343 A61K31/407 A61K31/416 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of linear tetracyclic heteroarene anthracehediones, which contain in side chains residues of halogen acetamidines and correspond to formula: as well as to their pharmacologically acceptable salts, where X, Y, Z independently stand for CH- or Nh-groups or heteroatoms, selected from O, N and S, forming five-member heteroarene, optionally substituted with alkyl; Hal independently stands for fluorine, chlorine, bromine or iodine atom; m and n independently stand for number from 2 to 4 and equal quantity of spacer CH₂-groups, connecting aminogroups in peri-positions of heteroarene anthracenedione with nitrogen atoms of residues of halogenacylamidines, located in side chain; W stands for substituents, independently selected from the group: amino, hydroxy, alkoxy, fluorine; k stands for number of substituents W in anthracenedione fragment, independently equal from 0.

EFFECT: novel compounds, which can be applied in medicine for therapy of oncological diseases, have been obtained.

3 tbl, 4 dwg, 12 ex