FIELD: chemical-pharmaceutical industry and technology, pharmacy.
SUBSTANCE: invention relates to a method for addition of difficultly water-soluble medicinal substances to the emulsion base. Method involves preliminary preparing solid dispersions by melting a medicinal substance and polyethylene glycol-1500 in the ratio = 1:(5-5.5) by mass at temperature no causing their destruction (90-140°C). Then solid dispersions are added to emulsion bases. Invention provides enhancing the pharmaceutical availability of difficultly water-soluble medicinal substances from soft medicinal formulations by 4-50.2 times and providing the better release due to enhanced solubility and rate of dissolving medicinal substances in preparing solid dispersions. This results to reducing dose and adverse effect of the medicinal substance on the body.
EFFECT: improved method for addition and preparing.
1 tbl, 3 dwg, 5 ex
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