TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMANS AND DERIVATIVES BY SIDE CHAINS AND THEIR USING Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of tocopherol, tocotrienol and other derivatives of chroman of the general formula (1): wherein X is taken among the group comprising oxygen and nitrogen atoms; Y is taken among the group comprising oxygen, nitrogen and sulfur atoms wherein if Y represents oxygen or nitrogen atom then n = 1 and if Y represents sulfur atom then n = 0; R¹ represents residue of carboxylic acid, carboxamide, ester, alcohol, amine or sulfate; R² represents methyl; R³ represents methyl; R⁴ represents methyl; R⁵ is taken among the group comprising alkyl, alkenyl, alkynyl, carboxyl and ester residue wherein if Y represents nitrogen atom then indicated nitrogen atom is replaced with group R⁶ wherein R⁶ represents hydrogen atom or methyl wherein if X represents oxygen atom, Y represents oxygen atom and R⁵ represents phytyl then R¹ doesn't mean butanoic acid. Also, invention relates to a pharmaceutical composition based on these compounds, a method for treatment of cellular-proliferative disease and a method for induction of cells apoptosis. Invention provides preparing new compounds possessing the proliferative effect.

EFFECT: valuable medicinal properties of compounds.

36 cl, 4 tbl, 19 dwg, 19 ex