TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMANS AND DERIVATIVES BY SIDE CHAINS AND THEIR USING Russian patent published in 2005 - IPC

Abstract RU 2263672 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of tocopherol, tocotrienol and other derivatives of chroman of the general formula (1): wherein X is taken among the group comprising oxygen and nitrogen atoms; Y is taken among the group comprising oxygen, nitrogen and sulfur atoms wherein if Y represents oxygen or nitrogen atom then n = 1 and if Y represents sulfur atom then n = 0; R1 represents residue of carboxylic acid, carboxamide, ester, alcohol, amine or sulfate; R2 represents methyl; R3 represents methyl; R4 represents methyl; R5 is taken among the group comprising alkyl, alkenyl, alkynyl, carboxyl and ester residue wherein if Y represents nitrogen atom then indicated nitrogen atom is replaced with group R6 wherein R6 represents hydrogen atom or methyl wherein if X represents oxygen atom, Y represents oxygen atom and R5 represents phytyl then R1 doesn't mean butanoic acid. Also, invention relates to a pharmaceutical composition based on these compounds, a method for treatment of cellular-proliferative disease and a method for induction of cells apoptosis. Invention provides preparing new compounds possessing the proliferative effect.

EFFECT: valuable medicinal properties of compounds.

36 cl, 4 tbl, 19 dwg, 19 ex

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RU 2 263 672 C2

Authors

Sanderz Robert Dzh.

Klajn Kimberli

Kherli Lorens

Gardner Robb

Menchaka Marla

Ju Vejping

Ramanan Putkhukod N.

Liu Shenkuan

Izraehl Karen

Dates

2005-11-10Published

2001-02-09Filed