FIELD: chemistry.
SUBSTANCE: invention describes prodrug compounds having a general structure: active agent - (acid)-(linker) - SO2NR1R2 :
where R1 represents H, C1-C12alkyl or C1-C12alkylC6-C10aryl; hAr represents C6-C10 aryl or 5-7 membered monocyclic heterocyclic ring or 7-10 membered bicyclic heterocyclic ring containing 1-4 heteroatoms selected from N, O and S; R2 represents H or C1-C12alkyl; R1 and R2 can be combined to form a 3-7-membered ring containing up to one heteroatom; each R3 and R4 independently represents H or C1-C12alkyl; X and Y represents H; Z represents O; and the active agent is androgen, estrogen or progestin.
EFFECT: compounds having this general structure (1) have a higher activity when administered orally than the unmodified parent molecule.
17 cl, 3 tbl
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