FIELD: biotechnology.
SUBSTANCE: invention describes recombinant host-cells comprising a chimerical gene involving the heterologous promoter sequence associated functionally with nucleic acid that encodes at least one polypeptide implicated in biosynthesis of epotilons, or polypeptide expressed by recombinant way and implicated in biosynthesis of epotilons, and Bac clones also. Using the invention provides to realize a method for preparing epotilons with high degree of effectiveness.
EFFECT: valuable properties of host-cell.
9 cl, 6 tbl, 15 ex
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