FIELD: biotechnologies.
SUBSTANCE: invention is related to the field of biotechnology, specifically, to separation and identification of new genes of spiramycins biosynthesis track and to new polypeptides, which participate in this biosynthesis, and may be used to produce acyltransferase, which is responsible for modification of platenolid in position 3. Polynucleotide coding acyltransferase, which is responsible for modification of platenolid in position 3, cells of bacterium Streptomyces type are transformed, and strain-producer of end polypeptide is made.
EFFECT: increased extent of production and purity of produced spiramycin.
26 cl, 41 dwg, 44 tbl, 31 ex
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Year |
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Number |
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|
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2003 |
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RU2236463C2 |
