DERIVATIVES OF QUINOLINE, METHOD FOR THEIR PREPARING AND THEIR USING, MEDICINAL AGENT AND METHOD FOR INHIBITION OF TUMOR CELL PROLIFERATION Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to new heteroaryl derivatives, in particular, derivatives of quinoline of he general formula (I): wherein R, R₁, R₂ and R₃ are similar or different and mean independently of one another hydrogen atom, linear or branched (C₁-C₈)-alkyl, halogen atom, aryl-(C₁-C₈)-alkoxy-group, aryl. Except for, R and R₁ or R₂ and R₃ can form six-membered aromatic ring condensed with quinoline residue; X means oxygen atom; p, Q mean in each case -CH₂-; X means nitrogen atom; n = 2; m = 0; R₄ means phenyl or pyridyl. Also, invention relates to their pharmaceutically acceptable salts, in particular, acid-additive salts. Compounds are useful as antitumor agents. Also, invention describes a method for preparing compounds and medicinal agent based on thereof.

EFFECT: improved preparing method, valuable medicinal properties of compounds and agent.

11 cl, 2 tbl, 13 ex