INDOLE DERIVATIVES, METHOD FOR THEIR PREPARING, MEDICINAL AGENT AND METHOD FOR INHIBITION OF TUMOR CELLS PROLIFERATION Russian patent published in 2006 - IPC C07D401/12 C07D403/12 C07D417/12 C07D409/12 A61K31/47 A61K31/38 A61K31/425 A61P35/00 

FIELD: organic chemistry, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to new derivatives of indole of the formula (1): wherein R means hydrogen atom (H), linear or branched (C₁-C₆)-alkylcarbonyl but preferably acetyl, linear or branched (C₁-C₆)-alkoxycarbonyl, (C₂-C₆)-alkynyl but preferably ethynyl or propargyl; R₁ means unsaturated or aromatic (C₃-C₁₀)-heterocycle comprising at least one heteroatom taken among nitrogen (N) and sulfur (S) atoms and possibly substituted with at least one linear or branched (C₁-C₆)-alkyl or (C₁-C₂)-alkoxy-group and wherein said heterocycle is joined to nitrogen amide atom directly with exception for of substituted or unsubstituted 2-, 4-pyrimidyl, substituted or unsubstituted 2-, 3-, 4-pyridyl, substituted or unsubstituted indolyl, substituted or unsubstituted dithiacyclopentyl, substituted or unsubstituted 2-, 3-, 4- or 8-quinolyl residues; R₂ means hydrogen atom (H) substituted with at least one phenyl, (C₁-C₆)-alkyl wherein phenyl residue can be free or comprises from 1 to 5 similar or different halogen atoms but preferably chlorine, bromine or iodine atoms; R₃ and R mean hydrogen atom; Z₁ and Z₂ mean independently oxygen or sulfur atoms. Also, invention relates to physiologically acceptable salts of the proposed compounds. Compounds of the formula (1) inhibit the tumor cells proliferation that allows their using as an antitumor medicinal agent. Also, invention describes a method for preparing compound of the formula (1).

EFFECT: improved preparing method, valuable medicinal properties of compounds and agent.

9 cl, 3 sch, 2 tbl, 18 ex