FIELD: organic chemistry of heterocyclic compounds, biochemistry, pharmacy. SUBSTANCE: invention relates to heterocyclic compound of the formula (I) 
wherein R1 represents C1-C6-alkyl, halogen atom, optionally substituted heterocyclic group or optionally substituted C6-C10-aryl; R2 represents carboxyl or hydroxyaminocarbonyl group; Ar represents phenyl or thienyl; A represents C1-C6-alkylene; X represents oxa-group or single bond; Y represents thia-group, sulfinyl or sulfonyl; Z represents methylene group; m and n each is a whole number from 0 to 1; m + n = 1 or 2; or its salt. Compounds can be used as inhibitors of matrix metalloproteinases or for preparing tumor necrosis factor-α. Also, invention describes pharmaceutical composition based on these compounds and method for their preparing. EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds. 9 cl, 1 tbl, 508 ex
| Title |
Year |
Author |
Number |
| PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF SYNTHESIS OF PEPTIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION |
1991 |
- Kejdzi Khemmi[Jp]
- Masakhiro Neja[Jp]
- Naoki Fukami[Jp]
- Masasi Khasimoto[Jp]
- Khirokazu Tanaka[Jp]
- Natsuko Kajakiri[Jp]
|
RU2092491C1 |
| AMIDES OF ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2000 |
|
RU2208608C2 |
| HETEROBICYCLIC DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
1995 |
- Norikhiko Simazaki
- Sinja Vatanabe
- Akikhiko Savada
- Kejdzi Khemmi
|
RU2170737C2 |
| SULFONAMIDE COMPOUND |
1998 |
- Kajakiri Khirosi
- Abe Josito
- Khamasima Khitosi
- Savada Khitosi
- Mizutani Tsujosi
- Jamasaki Noritsugu
- Onomura Osamu
- Nisikava Masakhiro
- Khiramura Takakhiro
- Oku Teruo
- Imoto Takafumi
|
RU2199532C2 |
| HETEROCYCLIC COMPOUNDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT |
1994 |
- Teruo Oku
- Khirosi Kajakiri
- Sigeki Satokh
- Josito Abe
- Juki Savada
- Takajjuki Inoju
- Khirokazu Tanaka
|
RU2135478C1 |
| OCTANE OXASPIRO [2,5]DERIVATIVE AND PROCESS FOR PREPARATION THEREOF (VARIANTS) |
1989 |
- Teruo Oku[Jp]
- Tiesi Kasakhara[Jp]
- Takekhiko Okhkava[Jp]
- Masasi Khasimoto[Jp]
|
RU2068412C1 |
| 1,2,3,4-TETRAHYDROPYRAZOLO-[5,1-C]-(1,2,4)-TRIAZINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION INHIBITING PRODUCING AN INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, METHOD OF PROPHYLACTIC OR THERAPEUTIC TREATMENT OF PATIENTS WITH DISEASES MEDIATED BY INTERLEUKIN AND TUMOR NECROSIS FACTOR |
1994 |
- Esio Kavai
- Khitosi Jamazaki
- Khirokazu Tanaka
- Teruo Oku
|
RU2124517C1 |
| AGENT WHICH PREVENTS PREMATURE OVULATION |
2006 |
- Furuja Suiti
- Kusaka Masami
|
RU2419435C2 |
| PYRROLIDINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
1991 |
- Khirojuki Setoi[Jp]
- Akikhiko Savada[Jp]
- Khirokazu Tanaka[Jp]
- Masaki Khasimoto[Jp]
|
RU2095346C1 |
| STAUROSPORIN DERIVATIVES USED FOR TREATING ALVEOLAR RHABDOMYOBLASTOMA |
2006 |
- Vakhtel' Marko
- Shafer Beat V.
- Amshtutts Ral'F
|
RU2443421C2 |
