FIELD: medicine, in particular vaccine of recombinant intracellular pathogens.
SUBSTANCE: invention relates to vaccine containing recombinant Calmette-Guerin bacillus (BCG), as well as method for prophylaxis of diseases associated with intracellular pathogen Mycobacterium tuberculosis. Disclosed is method for production of vaccine containing recombinant BCG having extrachromosomal DNA comprising gene encoding major Mycobacterium tuberculosis extracellular protein of 30 kD. Method for prophylaxis of mammalian diseases associated with intracellular pathogen Mycobacterium tuberculosis by administering of recombinant BCG expressing recombinant immunogenic antigens also is disclosed.
EFFECT: BCG of improved effectiveness.
6 cl, 4 ex, 7 tbl, 5 dwg
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