FIELD: chemistry; pharmacology.
SUBSTANCE: present invention pertains to biotechnology. Description is given of urease deficient cell Mycobacterium, a fused polypeptide producer, containing a recombinant nucleic acid molecule, which codes the fused polypeptide, containing a minimum of one polypeptide domain, capable of triggering an immune response in mammals, and an output domain from phagolysosomes. A pharmaceutical composition is invented, which is a live vaccine, containing the above described cell as the active agent, providing for protective immunity agains tuberculosis. A live vaccine method is proposed. A method of preparing the Mycobacterium cell described above is invented as well.
EFFECT: obtaining a safer vaccine for tuberculosis.
35 cl, 3 ex, 4 dwg
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