FIELD: biotechnology.
SUBSTANCE: vaccine strain of Mycobacterium bovis rBCG-1 is proposed, containing an artificial operon encoding the protectively significant proteins Mycobacterium tuberculosis ESAT-6, CFP-10, the yeast degradation signal Rpn4 under the secretion signal Ag85a and β-subunit of cholera toxin CtxB.
EFFECT: invention ensures formation of immunity to protective antigens of tuberculosis that are absent in BCG.
1 cl
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT PLASMID pESAT6-CFP10-DBD, RECOMBINANT STRAIN Escherichia coli M15 [pREP4, pESAT6-CFP10-DBD], METHOD FOR PREPARING, IMMOBILISING, CONCENTRATING AND PURIFYING RECOMBINANT PROTEIN ESAT6-CFP10-DBD ON DEXTRAN, RECOMBINANT PROTEIN ESAT6-CFP10-DBD AND IMMUNOGENIC COMPOSITION CONTAINING PROTEIN ESAT6-CFP10-DBD | 2013 |
|
RU2539026C1 |
| RECOMBINANT PLASMID, Escherichia coli STRAIN, CHIMERIC PROTEIN AND THEIR APPLICATION | 2010 |
|
RU2422525C1 |
| POLYANTIGENIC VACCINE FOR PREVENTING AND ADJUNCTIVE TREATMENT OF TUBERCULOSIS | 2019 |
|
RU2724896C1 |
| METHOD FOR PREDICTING TUBERCULOUS INFECTION, RECOMBINANT PLASMID DNA CODING THE SYNTHESIS OF CFP10-ESAT6 HYBRID PROTEIN OUT OF MYCOBACTERIUM TUBERCULOSIS, THE METHOD OF ITS OBTAINING, CFP10-ESAT6 HYBRID PROTEIN AND ITS APPLICATION | 2003 |
|
RU2277540C2 |
| METHOD FOR OBTAINING IMMUNOGENIC COMPOSITION BASED ON CFP10-DBD HYBRID PROTEIN AND DEXTRANE; pCFP10-DBD RECOMBINANT PLASMIDE; Escherichia coli [pREP4, pCFP10-DBD] STRAIN; CFP10-DBD CHIMERIC PROTEIN AND THEIR APPLICATION | 2013 |
|
RU2546875C1 |
| MULTI-EPITOPE POLYPEPTIDE FOR IMMUNIZATION AGAINST MYCOBACTERIUM TUBERCULOSIS | 2023 |
|
RU2824195C1 |
| RECOMBINANT PLASMID, Escherichia coli STRAIN, CHIMERIC PROTEIN AND THEIR APPLICATION | 2010 |
|
RU2422524C1 |
| RECOMBINANT TUBERCULOUS VACCINE AND ADJUVANT FOR IT | 2017 |
|
RU2665817C1 |
| HYBRID PROTEIN CFP10-ESAT6, INDUCING REACTION OF HYPERSENSITIVITY OF DELAYED TYPE WITH RESPECT TO M.Tuberculosis, CODING IT CHIMERIC NUCLEIC ACID AND RECOMBINANT PLASMID EXPRESSION VECTOR, CONTAINING IT, METHOD OF OBTAINING HYBRID PROTEIN AND BASED ON IT DOSED MEDICINAL FORM FOR INTRACUTANEOUS INJECTION | 2008 |
|
RU2360926C9 |
| METHOD FOR OBTAINING IMMUNOGENIC COMPOSITION BASED ON Ag85A-DBD HYBRID PROTEIN AND DEXTRANE; pAg85A-DBD RECOMBINANT PLASMIDE; Escherichia coli [pREP4, pAg85A-DBD] STRAIN; Ag85A-DBD CHIMERIC PROTEIN | 2013 |
|
RU2520078C1 |
