IMMUNOGENIC COMPOSITION (VERSIONS) BASED ON RECOMBINANT INTRACELLULAR PATHOGEN Russian patent published in 2008 - IPC A61K39/07 C12N15/63 C12N1/21

Abstract RU 2337707 C2

FIELD: medicine; pharmacology.

SUBSTANCE: presented are immunogenic compositions including recombinant attenuated intracellular pathogens, e.g. Calmette-Guérin bacillus (CGB). Immunogenic composition specifically includes CGB containing sequenced extrachromosomal nucleic acid which includes gene coding large extracellular mycobacteria protein sized 23.5, 30 and/or 32 kDa, thus large extracellular unmerged mycobacteria protein is superexpressed and secreted. Version is immunogenic composition containing recombinant CGB with controlled growth. Introduction of immunogenic compositions in mammal organism is associated with superexpression and secretion of specified proteins causing immune response of organism to introduced antigene.

EFFECT: immunogenic compositions provide reliable and safe protective immunity.

10 cl, 10 dwg 12 tbl, 6 ex

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RU 2 337 707 C2

Authors

Khorvits Markus A.

Khart Gjunter

Tullius Majkl V.

Dates

2008-11-10—Published

2003-09-30—Filed