VITAMIN D ANALOGS, PHARMACEUTICAL AND COSMETIC COMPOSITION CONTAINING THE SAME Russian patent published in 2005 - IPC

FIELD: pharmaceutical and cosmetic industries, biological aromatic vitamin D analogs.

SUBSTANCE: invention relates to compounds selected from group containing (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-in-2-ol, (3E,5E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, (E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-in-2-ol; and (3E,5E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, as well as from abovementioned compounds wherein one or more hydroxyl groups have protective group of formula -(C=O)-R, wherein R represents linear or branched C₁-C₆-alkyl, or C₆-C₁₀-aryl, or C₇-C₁₁-aralkyl; and aryl and aralkyl radicals may be substituted with one or two hydroxyl groups, C₁-C₃-alkoxy groups, halogen atoms, nitro or amino groups. Also disclosed are methods for application of said analogs in pharmaceutical composition with cell proliferation and differentiation activity useful in therapy and veterinary (i.e. dermatology, oncology, autoimmune diseases, organ and tissue transplantation), as well as in cosmetic composition.

EFFECT: vitamin D analogs with value pharmaceutical and cosmetic properties.

12 cl, 5 tbl, 6 dwg, 10 ex