FIELD: organic chemistry, vitamins.
SUBSTANCE: invention relates to novel triaromatic compounds, namely, analogs of vitamin D of the general formula (I): wherein values R1, R2, R3, X and Y are given in claim 1 of the invention claim. Also, invention relates to using these compounds in pharmaceutical compositions designated for treatment of the following diseases: (1) dermatological diseases associated with differentiation disturbance or proliferation of keratinocytes or sebocytes; (2) keratinization disorders; (3) dermatological diseases associated with disturbance of keratinization with inflammatory and/or immunoallergic components; (4) inflammatory diseases that don't represent keratinization disturbance; (5) cutaneous or epidermic expansion; (6) dermatological disorders, for example, vesicle dermatosis and collagenosis; (7) photoinduced or senile skin ageing, or for decreasing photoinduced pigmentations and keratosis, or any other pathologies associated with senile or photoinduced ageing; (8) skin healing and scar disturbances; (9) lipid function disturbances, such as acne hypersteatosis, simple seborrhea or seborrheic eczema; (10) dermatological diseases with immunologic component. Also, invention relates to cosmetic using the cosmetic composition for body and hair hygiene.
EFFECT: valuable medicinal and cosmetic properties of compounds.
16 cl, 3 tbl, 7 dwg, 10 ex
Title | Year | Author | Number |
---|---|---|---|
TRIAROMATIC ANALOGS OF VITAMIN D, PHARMACEUTICAL AND COSMETIC COMPOSITIONS | 2000 |
|
RU2237651C2 |
NOVEL CYCLOHEXANE DERIVATIVES | 2005 |
|
RU2382029C2 |
NOVEL HEXAFLUOROISOPROPANOL DERIVATIVES | 2005 |
|
RU2389718C2 |
INDOLYL DERIVATIVES AS LIVER X-RECEPTOR MODULATORS | 2005 |
|
RU2368612C2 |
VITAMIN D ANALOGUES | 2003 |
|
RU2364584C2 |
SUBSTITUTED PHENYL METHANONE DERIVATIVES | 2007 |
|
RU2437872C2 |
SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF HSL, EFFECTIVE FOR DIABETES TREATMENT | 2010 |
|
RU2607080C2 |
SELECTIVE GLYCOSIDASE INHIBITORS AND USE THEREOF | 2011 |
|
RU2592285C2 |
[4-(HETEROARYL)PIPERAZINE-1-YL]-(2,5-SUBSTITUTED PHENYL)METHANONE DERIVATIVES AS GLYCINE-1 (GLYT-1) CARRIER INHIBITORS FOR TREATING NEUROLOGIC AND PSYCHONEUROLOGICAL DISEASES | 2005 |
|
RU2396270C2 |
AMINE DERIVATIVES AND THEIR USE FOR TREATMENT OF OPHTHALMOLOGICAL DISEASES AND ILLNESSES | 2008 |
|
RU2536040C2 |
Authors
Dates
2007-06-27—Published
2002-12-06—Filed