METHOD FOR PREPARING SUBSTITUTED 3-META-PHENOXYPHENYL-1-PHENYL-2-PROPENE-1-ONES Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to chemistry of chalcone derivatives used in synthesis of biologically active substances, namely to a method for preparing m-phenoxybenzaldehyde-base chalcones of the general formula:

wherein R means hydrogen (H), bromine (Br), chlorine (Cl) atoms, -NO₂-group. Method involves interaction of m-phenoxybenzaldehyde with acetophenone or the corresponding substituted acetophenone, i. e.: bromoacetophenone, m-chloroacetophenone and m-nitroacetophenone. The process is carried out in the presence of sodium hydroxide as a catalyst in the mole ratio acetophenone or substituted acetophenone : m-phenoxybenzaldehyde : catalyst = (1.0-1.2):(1.2-1.5):(0.05-0.1), respectively. Mixture of dioxane with methanol taken in the mass ratio = 10:1 is used a solvent, and the process is carried out at room temperature for 20 h followed by isolation of the end product. Invention provides a single-step method with low energy consumption, high yield and purity of end products.

EFFECT: improved preparing method.

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