FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a method of producing 3-aroylcyclopropane-1,1,2,2-tetracarbonitriles of general formula 
(1), where R - Ph, 4-BrPh, 4-CH3OPh, 3,4-(CH3)2Ph, 3-NO2Ph, which can be used as biologically active substances, having anti-tumour activity with respect to cancer of the bowel, prostate, kidneys and ovaries. The method involves first mixing the corresponding acetophenone with dimethylsulphoxide and hydrobromic acid in molar ratio 1:12:4 at temperature 50-60°C, after which water is added and the reaction mass is heated to 90-95°C. A mixture consisting of a solution of bromine and malonodinitrile in molar ratio 1:2 in a mixture of ethanol and water is then added to the reaction mass.
EFFECT: method simplifies production of compounds of formula (1) due to realisation thereof in a single step.
5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROCESS OF OBTAINING METHYL ESTER 2-HALO-6-ALKYL-3-CYANOSUNICOTIN ACIDS | 2016 |
|
RU2616980C1 |
| METHOD OF PRODUCING 5-AMINO-3H-PYRROLE-4-CARBONONITRILES DERIVATIVES | 2018 |
|
RU2675600C1 |
| METHOD FOR PRODUCING 4-OXOALKANE-1,1,2,2-TETRACARBONITRILES | 2015 |
|
RU2577537C1 |
| METHOD OF PRODUCING 3-AMINO-8-HYDROXY-1,6-DIOXO-2,7-DIAZASPIRO[4,4]NON-3-ENE-4-CARBONITRILES | 2012 |
|
RU2495040C1 |
| METHOD OF OBTAINING 2-OXO-4-CYANO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDES | 2011 |
|
RU2475480C1 |
| METHOD OF PRODUCING 8-AMINO-1-IMINO-6-MORPHOLIN-4-YL-2-OXA-7-AZASPIRO[4,4]NONA-3,6,8-TRIENE-9-CARBONITRILES | 2011 |
|
RU2475489C1 |
| METHOD FOR PREPARING 6-IMINO-2,7-DIOXABICYCLO[3,2,1]OCTANE-4,4,5-TRICARBONITRILES | 2014 |
|
RU2545459C1 |
| METHOD OF PRODUCING 1-ALKYL-1-ALKOXY-2-ARYLCYLOPROPANES | 2009 |
|
RU2417215C2 |
| METHOD OF PRODUCING 4-ARYL-2-OXO-2H-CHROMENE-3-CARBONITRILES | 2015 |
|
RU2577524C1 |
| METHOD OF PRODUCING ALKYL-SUBSTITUTED 2-OXO-1,2-DIHYDROPYRIDINE-3,4-DICARBONITRILES | 2015 |
|
RU2577526C1 |
