COMPOUNDS CONTAINING A CONDENSED BICYCLIC RING, INTERMEDIATE COMPOUNDS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION FOR INHIBITION OF ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to compounds containing a condensed bicyclic ring of the formula (I) where A means a residue of the formula (a) or (b) where X means O or S; R₁ and R₁₂ - hydrogen, C_1-5-alkyl, phenyl-(lower)- -alkylene, naphthyl-(lower)-alkylene, C_3-7-cycloalkyl-(lower)- -alkylene, thienyl-(lower)-alkylene; or R₁ and R₁₂ taken together join C₅-C₆-cycloalkyl ring; R₂ - hydrogen or R₆ is C= O; R₃ and R₇ - hydrogen or lower alkyl; R₆ - lower alkyl; m and n = 0 or 1; Y is CH₂ or O; n = 1 or 2. Invention relates to also pharmaceutically acceptable salts of these compounds that are double-action inhibitors and show capability to inhibit activity of angiotensin-converting enzyme and neutral endopeptidase. EFFECT: improved methods of synthesis, enhanced effectiveness of compounds. 13 cl, 1 tbl, 32 ex