7-AZAINDOLES, THEIR USING AS INHIBITORS OF PHOSPHODIESTERASE 4 AND METHOD FOR THEIR PREPARING Russian patent published in 2006 - IPC C07D471/04 A61P11/00 A61K31/40 

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention describes new 7-azaindoles of the general formula (I): wherein n = 1 or 2; R¹ means mono- or multi-unsaturated, linear or branched (C₂-C₁₀)-alkenyl, linear or branched, unsubstituted (C₁-C₁₀)-alkyl that can be monosubstituted with (C₁-C₆)-alkoxy-group, naphthyl, pyridinyl, (C₃-C₆)-cycloalkyl, phenyl that, in turn, can be substituted with (C₁-C₆)-alkyl, halogen atom, (C₁-C₆)-alkoxy-group or hydroxy-group, or radical of the formula: ; R² and R³ are similar or different being only one of them can mean hydrogen atom and mean (C₁-C₅)-alkyl possibly substituted with -O-(C₁-C₆)-alkyl or pyridyl, phenyl possibly substituted twice with -F, -Cl, -Br, -O-(C₁-C₃)-alkyl or monosubstituted with -COOH or -COO-(C₁-C₃)-alkyl, pyridyl possibly twice substituted with -Cl, -Br, or group of formulae: or , or R² and R³ in common with N-atom mean: or under condition that if n = 1 then they don't mean simultaneously: R¹ - (C₁-C₆)-alkyl; R² - hydrogen atom (H) or (C₁-C₆)-alkyl, and R³ or wherein R and R' mean independently -Cl or -Br. These compounds possess inhibitory activity with respect to activity of phosphodiesterase 4. Also, invention relates to a medicinal agent comprising these compounds, methods for its preparing and using these compounds for preparing medicinal agents.

EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds and drug.

17 cl, 6 tbl, 40 ex