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IPC

A61K39/265(2006-01-01)

C12N7/00(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2004120862/13, 2004-07-09

(24)

Start date

2004-07-09

(22)

Actual filing date

2004-07-09

(45)

Published

2006-03-10

(72)

Inventor

Mishchenko Vladimir AleksandrovichGetmanskij Oleg IvanovichRuchnov Jurij Evgen'EvichKostyrkin Jurij AlekseevichNikeshina Tat'Jana BorisovnaZhbanova Tat'Jana Valentinovna

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Tsentr Okhrany Zdorov'Ja Zhivotnykh" Vniizzh)

EMULSION INACTIVATED VACCINE AGAINST INFECTIVE CATTLE RINOTRACHEITIS Russian patent published in 2006 - IPC A61K39/265 C12N7/00 A61P31/12 

Abstract RU 2271220 C1

FIELD: veterinary virology and biotechnology.

SUBSTANCE: claimed vaccine contains antigen material from infective cattle rinotracheitis virus strain, reproduced in specific passage cell cultures having biological activity of at least 6.0 lg TCD50/cm3 and inactivated with aminoethyl ethyleneimine, and oily adjuvant in mass ratio of 30.0:70.0, respectively. Aforementioned virus strain is reproduced in specific passage cell cultures and has cytopathic action and during incubation for 48-96 h in accumulated in titer of 6.5-8.0 lg TCD50/cm3. Aminoethyl ethyleneimine is used in concentration of 0.1-0.2 % followed by neutralization thereof with sodium thiosulfate.

EFFECT: vaccine with high antigenic and immunogenic activity and safety; enhanced assortment of specific agents for infective cattle rinotracheitis prophylaxis.

15 cl, 6 tbl, 7 ex

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RU 2 271 220 C1

Authors

Mishchenko Vladimir Aleksandrovich

Getmanskij Oleg Ivanovich

Ruchnov Jurij Evgen'Evich

Kostyrkin Jurij Alekseevich

Nikeshina Tat'Jana Borisovna

Zhbanova Tat'Jana Valentinovna

Dates

2006-03-10—Published

2004-07-09—Filed

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