NADL-ARRIAH VIRUS STRAIN OF BOVINE VIRAL DIARRHOEA FOR MAKING BIOPREPARATIONS FOR DIAGNOSIS, SPECIFIC PREVENTION AND TREATMENT OF BOVINE VIRAL DIARRHOEA Russian patent published in 2012 - IPC C12N7/00 A61K39/12 

FIELD: chemistry.

SUBSTANCE: invention relates to veterinarian virology and biotechnology. A novel industrial strain NADL-ARRIAH of bovine viral diarrhoea is obtained. The strain is deposited in the microorganisms used in veterinary and animal husbandry of FGU VGNKI under registration number - industrial strain NADL-ARRIAH-DEP bovine viral diarrhoea. The strain is reproduced in passaged cultures of calf kidney cells, saiga finite cell line, intestinal mucus finite cell line, intraspecific swine embryo kidney hybrid finite cell line with swine splenocyte (A₄×C₂) at 37°C and in 72-96 hour of incubation, the virus accumulates therein in amount of 6.0-7.0 lg TCD₅₀/cm³. The strain is stable and retains its properties for 10 passages. The strain is used to obtain hyperimmune blood serum to bovine viral diarrhoea on rabbit and guinea pigs, used for agent diagnosis and treating animal diseases.The invention can be used in veterinary.

EFFECT: inactivated emulsion vaccine derived from said strain protects immunised animals from direct infection by a virulent virus.

1 dwg, 10 tbl, 7 ex